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- Title
Magnifying endoscopy with narrow-band imaging is useful in differentiating gastric cancer from matched adenoma in white light imaging.
- Authors
Tamura, Naoki; Sakaguchi, Yoshiki; Furutani, Wakiko; Matsui, Maki; Nagao, Sayaka; Sakuma, Nobuyuki; Fukagawa, Kazushi; Miura, Yuko; Mizutani, Hiroya; Ohki, Daisuke; Kataoka, Yosuke; Saito, Itaru; Ono, Masayoshi; Minatsuki, Chihiro; Tsuji, Yosuke; Ono, Satoshi; Kodashima, Shinya; Abe, Hiroyuki; Ushiku, Tetsuo; Yamamichi, Nobutake
- Abstract
This study assessed the effect of magnifying endoscopy with narrow-band imaging (M-NBI) on the endoscopic differential diagnosis between intramucosal gastric carcinomas and adenomas with matched characteristics. Associations between magnified endoscopic findings and pathological high-grade cellular and architectural atypia were also investigated. In total, the records of 50 adenomas and 50 intramucosal well-differentiated adenocarcinomas matched by tumor size (≥ 20 mm or < 20 mm), shape (depression or non-depression), and color (red or non-red) were extracted. Fourteen endoscopists diagnosed adenoma or cancer in the 100 cases with conventional white light imaging (C-WLI), then did the same with C-WLI + M-NBI.The cancer diagnostic sensitivity, specificity, and accuracy were assessed. The sensitivity of C-WLI + M-NBI for cancer diagnosis was 79.9% compared to 71.6% with C-WLI (p < 0.001). There were no significant differences in specificity (40.1% vs. 36.3%, p = 0.296) and accuracy (55.9% vs. 58.1%, p = 0.163). High-grade cytological or architectural atypia was diagnosed more often with irregular microvascular pattern (IMVP) or microsurface pattern (IMSP), respectively, than the low-grade forms. In conclusion, IMVP and IMSP correlate with high-grade cytological and architectural atypia. M-NBI is useful in differentiating intramucosal carcinoma from adenoma and can reduce underdiagnosis of cancer.
- Subjects
STOMACH cancer; ADENOMA; ENDOSCOPY; GASTRIC mucosa; CANCER diagnosis; DIFFERENTIAL diagnosis
- Publication
Scientific Reports, 2022, Vol 12, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-022-12315-0