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- Title
Synthesis, Characterization and Biological Evaluation of N'-Substituted-2-(5-(4- substitutedphenyl)-1,3,4-Oxadiazol-2-ylthio)acetohydrazide Derivatives.
- Authors
Rasool, Shahid; Aziz-ur-Rehman; Abbasi, Muhammad Athar; Siddiqui, Sabahat Zahra; Ahmad, Irshad; Malik, Rabia; Khan, Khalid Mohammed
- Abstract
Hydrazone derivatives bearing heterocyclic moiety have been synthesized to evaluate their antibacterial and enzyme inhibition activity. Two p-substituted carboxylic acids (1a and 1b) have been utilized to synthesize ethyl esters (2a and 2b), carbohydrazides (3a and 3b), 5- substituted-1,3,4-oxadiazol-2-thiols (4a and 4b), heterocyclic ethyl esters (5a and 5b) and finally acetohydrazides (6a and 6b). The final hydrazone derivatives, 8a-j and 9a-j, were synthesized by the reaction of 6a and 6b with different un/mono substituted benzaldehydes (7a-j) in methanol. The synthesized compounds were characterized by spectral data of IR, 1H-NMR and EIMS. The evaluation of these molecules for their antibacterial and lipoxygenase inhibition activities rendered 8g suitable antibacterial agent and lipoxygenase inhibitor and the remaining ones as moderate inhibitors.
- Subjects
OXADIAZOLES; CARBOXYLIC acids; ANTIBACTERIAL agents; LIPOXYGENASES; ENZYMES
- Publication
Journal of the Chemical Society of Pakistan, 2016, Vol 38, Issue 1, p80
- ISSN
0253-5106
- Publication type
Article