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- Title
The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection.
- Authors
Du, Ying; Thompson, Ethan G.; Muller, Julius; Valvo, Joseph; Braun, Jackie; Shankar, Smitha; van den Berg, Robert A.; Jongert, Erik; Dover, Drew; Sadoff, Jerald; Hendriks, Jenny; Gardner, Malcolm J.; Ballou, W. Ripley; Regules, Jason A.; van der Most, Robbert; Aderem, Alan; Ockenhouse, Christian F.; Hill, Adrian V.; Wille-Reece, Ulrike; Zak, Daniel E.
- Abstract
The RTS,S/AS01 vaccine provides partial protection against Plasmodium falciparum infection but determinants of protection and/or disease are unclear. Previously, anti-circumsporozoite protein (CSP) antibody titers and blood RNA signatures were associated with RTS,S/AS01 efficacy against controlled human malaria infection (CHMI). By analyzing host blood transcriptomes from five RTS,S vaccination CHMI studies, we demonstrate that the transcript ratio MX2/GPR183, measured 1 day after third immunization, discriminates protected from non-protected individuals. This ratiometric signature provides information that is complementary to anti-CSP titer levels for identifying RTS,S/AS01 immunized people who developed protective immunity and suggests a role for interferon and oxysterol signaling in the RTS,S mode of action.
- Subjects
MALARIA; MALARIA vaccines; INFECTION; PLASMODIUM falciparum; INTERFERONS
- Publication
Frontiers in Immunology, 2020, Vol 11, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2020.00669