We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
ACTIVITIES OF IMMUNOSUPPRESSIVE AGENTS <em>IN VITRO</em> II. DIFFERENT TIMING OF AZATHIOPRINE AND METHOTREXATE IN INHIBITION AND STIMULATION OF MIXED LYMPHOCYTE REACTION.
- Authors
Bach, Marie-anne; Bach, J.-F.
- Abstract
Azathioprine (AZ) and Methotrexate (MTX) inhibit thymidine incorporation in mixed lymphocyte reaction (MLR) at non-cytotoxic concentrations. AZ is active only when introduced in the culture during the first 24 hr, whereas MTX is still active when introduced all day 4. These data indicate that AZ might act on antigen recognition by T cells, as previously suggested by its effects on inhibition of rosette formation, and not on cell proliferation, as MTX probably does. Stimulation of thymidine incorporation has been observed at low drug concentrations, especially when the drugs were added more than 24 hr after the beginning of the culture, and most particularly for MTX added 6 days after start of the culture.
- Subjects
METHOTREXATE; HETEROCYCLIC compounds; FOLIC acid antagonists; IMMUNOSUPPRESSIVE agents; THYMIDINE; THYMINE
- Publication
Clinical & Experimental Immunology, 1972, Vol 11, Issue 1, p89
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/1365-2249.ep14545199