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- Title
Frequency of Cytomegalovirus Viral Load in Iranian Human Immunodeficiency Virus-1-Infected Patients with CD4+ Counts <100 Cells/mm<sup>3</sup>.
- Authors
Jabbari, Mohammad Reza; Soleimanjahi, Hoorieh; Shatizadeh Malekshahi, Somayeh; Gholami, Mohammad; Sadeghi, Leila; Mohraz, Minoo
- Abstract
Objectives: The aim of present work was to assess cytomegalovirus (CMV) viremia in Iranian human immunodeficiency virus (HIV)-1-infected patients with a CD4+ count <100 cells/mm3 and to explore whether CMV DNA loads correlate with CD4+ cell counts or associated retinitis. Methods: This study was conducted at the AIDS research center in Iran on HIV-1-infected patients with CD4+ count <100 cells/mm3, antiretroviral therapy-naive, aged ≥18 years with no previous history of CMV end-organ disease (CMV-EOD). Results: Thirty-nine of 82 patients (47.56%) had detectable CMV viral load ranging from 66 to 485,500 IU/mL. CMV viral load in patients with retinitis ranges from 352 to 2,720 IU/mL, and it was undetectable in 2 patients. No significant associations between CMV viremia and CD4+ cell count was found (p value = 0.31), whereas significant association of CMV viremia in HIV-infected patients with retinitis was found (p < 0.02). Conclusions: We estimated the frequency of CMV viral load infection in Iranian HIV-1-infected patients with a CD4+ cell count <100 mm3/mL in the largest national referral center for HIV-1 infection in Iran. Further research is required on the relevance of CMV viral load in diagnostic and prognostic value of CMV-EOD.
- Subjects
IRAN; HIV; CYTOMEGALOVIRUSES; VIRAL load; CYTOMEGALOVIRUS diseases; PROGNOSIS; VIRUS diseases; IRANIANS; IMMUNODEFICIENCY
- Publication
Intervirology, 2021, Vol 64, Issue 3, p135
- ISSN
0300-5526
- Publication type
Article
- DOI
10.1159/000514385