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- Title
Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease: a distinct inflammatory response from erythema nodosum.
- Authors
Yamasaki, O.; Morizane, S.; Aochi, S.; Ogawa, K.; Oono, T.; Iwatsuki, K.
- Abstract
Summary Background. Cytotoxic T lymphocytes (CTLs) have been recognized as an important effector cell in Behçet disease (BD). Granulysin is a cytolytic granule protein expressed by CTLs and natural killer cells. Aim. To evaluate the involvement of granulysin-producing T cells in the pathogenesis of BD. Methods. Using immunohistochemistry, lymphocyte subsets expressing granulysin were investigated in mucocutaneous lesions of BD. Serum granulysin levels were assayed by ELISA. Results. Granulysin-positive cells were seen in specimens from oral ulcers, genital ulcers and acne-like eruptions, but not erythema nodosum-like lesions. Both CD4+ and CD8+ T cells expressed granulysin. Serum granulysin levels did not correlate with disease activity in BD. Conclusion. Immune reactions mediated by granulysin-positive CTLs may play an important role in the pathogenesis of acne-like eruptions, oral ulcers and genital ulcers in BD.
- Subjects
T cells; ERYTHEMA; LEUCOCYTES; CELL-mediated cytotoxicity; LYMPHOCYTES; ENZYME-linked immunosorbent assay; IMMUNOHISTOCHEMISTRY
- Publication
Clinical & Experimental Dermatology, 2011, Vol 36, Issue 8, p903
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.2011.04159.x