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- Title
Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.
- Authors
Wei Jie Seow; Keitaro Matsuo; Chao Agnes Hsiung; Kouya Shiraishi; Minsun Song; Hee Nam Kim; Maria Pik Wong; Yun-Chul Hong; Hosgood III, H. Dean; Zhaoming Wang; I-Shou Chang; Jiu-Cun Wang; Chatterjee, Nilanjan; Tucker, Margaret; Hu Wei; Tetsuya Mitsudomi; Wei Zheng; Jin Hee Kim; Baosen Zhou; Caporaso, Neil E.
- Abstract
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10−8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.
- Publication
Human Molecular Genetics, 2017, Vol 26, Issue 2, p454
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/ddw414