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- Title
Ultra Short-Loop Feedback Control of Thyrotropin Secretion.
- Authors
Mark F. Prummel; Leon J.S. Brokken; Wilmar M. Wiersinga
- Abstract
Evidence is accumulating that pituitary hormone secretion is not only regulated by feedback from hormonesproduced in the target organs (long feedback) on the pituitary and the hypothalamus (feedforward), but alsoby a feedback of the hypophyseal hormones at the hypothalamic (short feedback) and the pituitary (ultra-shortfeedback) level. Inhibition of thyrotropin (TSH) and MSH secretion by pituitary preparations by adding exogenousTSH or MSH to the medium was already observed in the 1960s, as was the phenomenon that adrenocorticotropichormone (ACTH) injected in the hypothalamus lowered plasma corticosterone levels. These earlyobservations have now been corroborated by the demonstration of the receptors for various pituitary hormonesin the hypothalamus and the adenohypophysis. The thyrotropin receptor (TSHR) is found on folliculo-stellatecells in the pituitary, which are known to influence the neighboring endocrine cells. This pituitary TSR-receptoris also recognized by TSHR receptor autoantibodies, which can downregulate TSH secretion independentlyfrom thyroid hormone levels, and are therefore thought to be responsible for the frequently observed suppressedTSH levels in patients with Graves' disease who are otherwise euthyroid.
- Publication
Thyroid, 2004, Vol 14, Issue 10, p825
- ISSN
1050-7256
- Publication type
Article