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- Title
Differences in Salivary Cortisol Levels in Cocaine-Exposed and Noncocaine-Exposed NICU Infants.
- Authors
Magnano, Catherine L.; Gardner, Judith M.; Karmel, Bernare Z.
- Abstract
To assess whether cocaine exposure in utero affected adrenocortical responsiveness in the neonatal period, salivary cortisol levels were compared between non cocaine-exposed (n = 35) and cocaine-exposed (n = 11) healthy preterm infants just prior to hospital discharge. Cortisol levels were measured under three conditions: Basal--120 min after no disrupting event or behavioral distress; Noninvasive Stressor--30 min after a neurobehavioral examination; Invasive Stressor--30 min after a heel-stick procedure. There were no differences in Basal cortisol levels between the non cocaine-exposed and cocaine-exposed infants, but the cocaine-exposed infants had significantly lower levels in both the Noninvasive and Invasive Stressor conditions. The suppressed cortisol responding to stressful events in cocaine-exposed infants suggests that these infants may have decreased modulation capability to normally stressful events, which could underlie some of the subtle state regulation problems reported.
- Subjects
HYDROCORTISONE; NEWBORN infants; COCAINE; DISTRESS in infants; BEHAVIORAL assessment; SALIVA
- Publication
Developmental Psychobiology, 1992, Vol 25, Issue 2, p93
- ISSN
0012-1630
- Publication type
Article
- DOI
10.1002/dev.420250203