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- Title
Monitoring cancer stem cells: insights into clinical oncology.
- Authors
ShuChen Lin; YingChun Xu; ZhiHua Gan; Kun Han; HaiYan Hu; Yang Yao; MingZhu Huang; DaLiu Min
- Abstract
Cancer stem cells (CSCs) are a small, characteristically distinctive subset of tumor cells responsible for tumor initiation and progression. Several treatment modalities, such as surgery, glycolytic inhibition, driving CSC proliferation, immunotherapy, and hypofractionated radiotherapy, may have the potential to eradicate CSCs. We propose that monitoring CSCs is important in clinical oncology as CSC populations may reflect true treatment response and assist with managing treatment strategies, such as defining optimal chemotherapy cycles, permitting pretreatment cancer surveillance, conducting a comprehensive treatment plan, modifying radiation treatment, and deploying rechallenge chemotherapy. Then, we describe methods for monitoring CSCs.
- Subjects
CANCER stem cells; CANCER cell proliferation; CANCER invasiveness; IMMUNOTHERAPY; RADIOTHERAPY; CANCER chemotherapy
- Publication
OncoTargets & Therapy, 2016, Vol 9, p731
- ISSN
1178-6930
- Publication type
Article
- DOI
10.2147/OTT.S96645