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- Title
Sarcoglycans and integrins in human thyrocytes: an immunofluorescence study.
- Authors
Favaloro, Angelo; Rizzo, Giuseppina; Santoro, Giuseppe; Pergolizzi, Simona; Furci, Antonio; Centofanti, Antonio; Cutroneo, Giuseppina
- Abstract
The sarcoglycan sub-complex is a protein system which plays a key role in sarcolemma stabilization during muscle activity consisting of six glycosylated transmembrane proteins. Integrins play a key role in the process of cell adhesion, linking the extracellular matrix to the actin cytoskeleton. Here we have analysed the receptor for thyroid hormone, identif ed on αvβ3- integrin that has an important role in the activation of non-genomic actions of the hormone. Many non-genomic actions of the thyroid hormone appear to contribute to basal levels of activity of a variety of proteins, including ion pumps, intracellular protein traf cking and protein turnover. The purpose of our research was to study the presence and behaviour of sarcoglycans and integrins on the thyroid gland, in both normal and pathological conditions, for the f rst time. Our results show a normal fiuorescence pattern in patients without pathology, and a reduced fluorescence pattern in patients with thyroid disease. Moreover, colocalization in healthy patients was found in double localization reactions, whereas in patients with Hashimoto’s thyroiditis sarcoglycans did not colocalize with tested integrin. These data could confirm the hypothesis of a close association between sarcoglycans and integrins, which, in pathological condition, are not found contemporarily hypothesizing that each single protein system could have a role in maintaining cell vitality.
- Subjects
THYROID hormone receptors; MEMBRANE proteins; INTEGRINS; AUTOIMMUNE thyroiditis; IMMUNOFLUORESCENCE; CELL adhesion; HORMONE receptors
- Publication
Italian Journal of Anatomy & Embryology / Archivio Italiano di Anatomia Ed Embriologia, 2022, Vol 126, Issue 1, p125
- ISSN
1122-6714
- Publication type
Article
- DOI
10.36253/ijae-13681