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- Title
Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma.
- Authors
Sheu, Bor-Ching; Hsu, Su-Ming; Ho, Hong-Nerng; Lin, Rong-Hwa; Torng, Pao-Ling; Huang, Su-Cheng; Sheu, B C; Hsu, S M; Ho, H N; Lin, R H; Torng, P L; Huang, S C
- Abstract
<bold>Background: </bold>To investigate the clinical significance of tumor-infiltrating lymphocytes (TILs) within the tumor milieu of human cervical carcinoma, the authors quantitatively measured and compared the subpopulations of lymphocytes infiltrating the neoplastic cervix.<bold>Methods: </bold>A total of 30 patients with Stage Ia-IIa cervical carcinoma were enrolled. TILs were isolated from tissue specimens by means of a mechanical dispersal technique, and the immunocyte subsets were quantified with dual-color flow cytometry. Bulky tumor was defined as tumor size >4 cm in greatest dimension according to the 1995 staging of the International Federation of Gynecology and Obstetrics.<bold>Results: </bold>The CD4/CD8 ratios of TILs were reversed in both cervical squamous cell carcinoma (n = 20) and cervical adenocarcinoma (n = 10). The proportion of CD4(+) T cells was significantly lower in tumors from patients with lymph node metastasis (n = 8) than in those from patients without lymph node metastasis (n = 22) (24.5 vs. 32.7, P = 0.001), as was the reversed CD4/CD8 ratio (0.50 vs. 0.81, P = 0.001). The proportion of CD4(+) T cells was much lower in bulky tumors (n = 5) than in nonbulky tumors (n = 25) (21.4 vs. 32.5, P < 0.001), reflecting in a more strongly reversed CD4/CD8 ratio (0.41 vs. 0.81, P = 0.001).<bold>Conclusions: </bold>Decreased proportions of tumor-infiltrating CD4+ T cells with reversed CD4/CD8 ratios are highly correlated with rapid tumor growth and lymph node metastasis in cervical carcinoma. The regional immune escape is of prognostic importance with regard to cancer progression.
- Subjects
ADENOCARCINOMA; DISEASE progression; RESEARCH; RESEARCH methodology; METASTASIS; KILLER cells; LYMPH nodes; EVALUATION research; MEDICAL cooperation; LYMPHOCYTES; TUMOR classification; COMPARATIVE studies; IMMUNOPHENOTYPING; CERVIX uteri tumors; SQUAMOUS cell carcinoma; LYMPHOCYTE subsets; LYMPHOCYTE count
- Publication
Cancer (0008543X), 1999, Vol 86, Issue 8, p1537
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/(SICI)1097-0142(19991015)86:8<1537::AID-CNCR21>3.0.CO;2-D