We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Intermittent Pamidronate Treatment in Thalassaemia-induced Osteoporosis.
- Authors
Patýroðlu, Türkan; Altuner Torun, Yasemin; Demir, Hüseyin; Karakükçü, Musa; Kula, Mustafa
- Abstract
Purpose: In this study, we determined osteoporosis by Dual Energy X-Ray (DXA) and the effectiveness of pamidronate treatment in 24 thalassaemic patients in the Pediatric Hematology Unit of Erciyes University. Material and Methods: Twenty-four thalassaemic patients with an age range of 6-22 years (14 girl, 10 boy, mean age: 11.20 ± 3,9) were included in the study. Bone mineral densities of lumbar vertebrae L1-L4 and femur neck were measured by DXA method. Z score of bone mineral densities of vertebrae L1-L4 was below .2.5 in 9 patients (37.5 %), -1 to .2.5 in 14 patients (58.3%) and was normal in one patient. Pamidronate treatment (15 mg/dose for patients at age 15 below, 30 mg/dose at age above 15, per three months for one year) was given to 23 osteoporotic (Z score below .2,5) and osteopenic (Z score .1 to .2,5) patients with bone pain and history of bone fracture. Results: The mean Z score of L1-L4 was -2.34 ± 0.77 (Mean BMD: 0.555 ± 0.106) at the beginning and -2.17 ± 0.88 (Mean BMD: 0.587 ± 0.107) after one year. There was a statistically significant difference between results of BMD at the beginning and after 12 months. Conclusion: Pamidronate treatment is effective in thalassaemia-induced osteoporosis.
- Subjects
OSTEOPOROSIS treatment; TREATMENT effectiveness; THALASSEMIA; BONE density; X-rays; DISODIUM pamidronate; PATIENTS
- Publication
Erciyes Medical Journal / Erciyes Tip Dergisi, 2010, Vol 32, Issue 2, p87
- ISSN
2149-2247
- Publication type
Article