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- Title
Microvascular impairments detected by optical coherence tomography angiography in multiple sclerosis patients: A systematic review and meta-analysis.
- Authors
Jing Liu; Shuang Song; Xiaoya Gu; Hui Li; Xiaobing Yu
- Abstract
Purpose: A systematic review and meta-analysis was conducted to investigate changes in retinal and choroidal microvasculature in patients with multiple sclerosis (MS) using optical coherence tomography angiography (OCTA). Methods: PubMed and Google Scholar were searched for studies that compared retinal and choroidal microvasculature between MS and healthy controls (HC) with OCTA. MS patients were divided into 2 groups: MS with (MSON) or without optic neuritis (MSNON). Results: Totally, 13 studies including 996MS eyes and 847 HC eyes were included. Compared with the HC, the vessel density of the whole superficial vascular complex (SVC) was reduced by 2.27% and 4.30% in theMSNON andMSON groups, respectively. The peripapillary vessel density was 2.28% lower and 4.96% lower in the MSNON and MSON groups, respectively, than in the HC. Furthermore, the MSON group had significant lower vessel density of the SVC (mean di
- Subjects
OPTICAL coherence tomography; MULTIPLE sclerosis; OPTIC neuritis; ANGIOGRAPHY
- Publication
Frontiers in Neuroscience, 2023, Vol 16, p1
- ISSN
1662-4548
- Publication type
Article
- DOI
10.3389/fnins.2022.1121899