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- Title
Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus.
- Authors
Sun-Woo Yoon; Sook-San Wong; Huachen Zhu; Rirong Chen; Long Li; Yu Zhang; Yi Guan; Richard J. Webby; Yoon, Sun-Woo; Wong, Sook-San; Zhu, Huachen; Chen, Rirong; Li, Long; Zhang, Yu; Guan, Yi; Webby, Richard J
- Abstract
Pregnancy has been associated with severe influenza, an association highlighted during the 2009 pandemic of influenza A(H1N1) virus (A[H1N1]pdm09) infection. To assess the underlying mechanism, we infected pregnant and non-pregnant ferrets with A(H1N1) pdm09 virus. A(H1N1)pdm09-infected pregnant ferrets also had higher levels of inflammatory cytokines in their pulmonary tracts. Systemically, total CD8+ T cell counts and A(H1N1)pdm09-specific B-cell responses in blood were significantly lower in pregnant ferrets. This model predicts that the poorer outcome for pregnant women during the A(H1N1)pdm09 pandemic was due to an elevated level of viral replication and to a cytokine imbalance that led to a less effective immune response.
- Subjects
PREGNANCY complications; H1N1 influenza; INFLUENZA A virus; IMMUNE response; CYTOKINES; FERRETS as laboratory animals; ANIMAL experimentation; B cells; BIOLOGICAL models; COMMUNICABLE diseases; LUNGS; MAMMALS; T cells; INFLUENZA A virus, H1N1 subtype; ORTHOMYXOVIRUS infections
- Publication
Journal of Infectious Diseases, 2018, Vol 217, Issue 3, p438
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jix328