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- Title
Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset.
- Authors
Zhe Chen; Linlin Bao; Cong Chen; Tingting Zou; Ying Xue; Fengdi Li; Qi Lv; Songzhi Gu; Xiaopan Gao; Sheng Cui; Jianmin Wang; Chuan Qin; Qi Jin; Chen, Zhe; Bao, Linlin; Chen, Cong; Zou, Tingting; Xue, Ying; Li, Fengdi; Lv, Qi
- Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans is highly lethal, with a fatality rate of 35%. New prophylactic and therapeutic strategies to combat human infections are urgently needed. We isolated a fully human neutralizing antibody, MCA1, from a human survivor. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). To our knowledge, this study is the first to report a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets. Monotherapy with MCA1 represents a potential alternative treatment for human infections with MERS-CoV worthy of evaluation in clinical settings.
- Subjects
MONOCLONAL antibodies; MIDDLE East respiratory syndrome; CALLITHRIX jacchus; BINDING site assay; CD26 antigen; DISEASES
- Publication
Journal of Infectious Diseases, 2017, Vol 215, Issue 12, p1807
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jix209