We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells.
- Authors
Fernandez S; Tanaskovic S; Helbig K; Rajasuriar R; Kramski M; Murray JM; Beard M; Purcell D; Lewin SR; Price P; French MA; Fernandez, Sonia; Tanaskovic, Sara; Helbig, Karla; Rajasuriar, Reena; Kramski, Marit; Murray, John M; Beard, Michael; Purcell, Damian; Lewin, Sharon R
- Abstract
Most patients with human immunodeficiency virus (HIV) who remain CD4(+) T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD4(+) T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-α), we examined these factors in HIV patients with good or poor CD4(+) T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD4(+) T cells of patients with poor CD4(+) T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls. Poor CD4(+) T-cell recovery was also associated with CD4(+) T-cell expression of markers of activation, senescence, and apoptosis, and with increased serum levels of the lipopolysaccharide receptor and soluble CD14, but these were not significantly correlated with expression of the interferon-stimulated genes. Therefore, CD4(+) T-cell recovery may be adversely affected by the effects of IFN-α, which may be amenable to therapeutic intervention.
- Subjects
RNA metabolism; ANTIRETROVIRAL agents; ANTIGENS; APOPTOSIS; CELLS; GENE expression; HIV infections; IMMUNOLOGY technique; LIPIDS; PROTEINS; T cells; HLA-B27 antigen; CROSS-sectional method; ANTI-HIV agents; CD4 lymphocyte count
- Publication
Journal of Infectious Diseases, 2011, Vol 204, Issue 12, p1927
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jir659