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- Title
I- mIBG Scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: Design of two prospective multicenter international trials.
- Authors
Jacobson, Arnold F.; Lombard, John; Banerjee, Gopa; Camici, Paolo G.
- Abstract
Background: ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) consists of two identical prospective open-label, multicenter, phase 3 studies (MBG311 and MBG312) evaluating the prognostic usefulness of I- mIBG scintigraphy for identifying subjects with heart failure who will experience a major adverse cardiac event. Methods: Subjects with NYHA class II and III heart failure and left ventricular ejection fraction ≤35% were eligible for the trials. Subjects underwent planar and SPECT I- mIBG myocardial imaging, as well as echocardiography and gated SPECT Tc-tetrofosmin myocardial perfusion imaging. Subjects are then monitored on a regular basis for 2 years. Time to first occurrence of one of the following-NYHA class progression; potentially life-threatening arrhythmic event (including ICD discharge); or cardiac death, as verified by an independent adjudication panel-will be analyzed in comparison to quantitative parameters derived from I- mIBG imaging. The primary efficacy analysis will employ the heart/mediastinum ratio on 4-hour delayed planar imaging, while secondary efficacy analyses will examine quantitative results from both planar and SPECT I- mIBG images, as well as from Tc-tetrofosmin SPECT and echocardiography. Conclusion: The results of the ADMIRE-HF trials will provide prospective validation of the potential role of I- mIBG scintigraphy in assessing prognosis and developing management strategies for patients with heart failure.
- Subjects
HEART failure; HEART diseases; CARDIAC arrest; CONGESTIVE heart failure; MYOCARDIAL infarction
- Publication
Journal of Nuclear Cardiology, 2009, Vol 16, Issue 1, p113
- ISSN
1071-3581
- Publication type
Article
- DOI
10.1007/s12350-008-9008-2