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- Title
Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium.
- Authors
Park, J. Y.; Dahm, C. C.; Keogh, R. H.; Mitrou, P. N.; Cairns, B. J.; Greenwood, D. C.; Spencer, E. A.; Fentiman, I S; Shipley, M. J.; Brunner, E. J.; Cade, J. E.; Burley, V. J.; Mishra, G. D.; Kuh, D; Stephen, A. M.; White, I. R.; Luben, R. N.; Mulligan, A. A.; Khaw, K-T; Rodwell, S. A.
- Abstract
<bold>Background: </bold>Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent.<bold>Methods: </bold>We investigated the prospective associations between alcohol intake on overall and site- and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ).<bold>Results: </bold>Compared with individuals in the lightest category of drinkers (>0-<5 g per day), the multivariable odds ratios of CRC were 1.16 (95% confidence interval (95% CI): 0.88, 1.53) for non-drinkers, 0.91 (95% CI: 0.67, 1.24) for drinkers with 5-<15 g per day, 0.90 (95% CI: 0.65, 1.25) for drinkers with 15-<30 g per day, 1.02 (95% CI: 0.66, 1.58) for drinkers with 30-<45 g per day and 1.19 (95% CI: 0.75, 1.91) for drinkers with >or=45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results.<bold>Conclusion: </bold>We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.
- Subjects
UNITED Kingdom; PHYSIOLOGICAL effects of alcohol; COLON cancer risk factors; FOOD diaries; COHORT analysis; SEX differences (Biology); COLON tumors; COMPARATIVE studies; DIET; ALCOHOL drinking; RESEARCH methodology; MEDICAL cooperation; QUESTIONNAIRES; RECTUM tumors; RESEARCH; RESEARCH funding; SMOKING; EVALUATION research; CASE-control method
- Publication
British Journal of Cancer, 2010, Vol 103, Issue 5, p747
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6605802