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- Title
Immunohistochemical Evaluation of a Panel of Tumor Cell Markers During Malignant Progression in Barrett Esophagus.
- Authors
Herman van Dekken; Wim Hop; Hugo Tilanus; Jelle Haringsma; Hans van der Valk; Josiane Wink; Kees Vissers
- Abstract
Histopathologic grading of dysplasia in Barrett esophagus (BE) shows substantial interobserver and intraobserver variation. We used immunohistochemical analysis with a set of tumor cell markers, ie, epidermal growth factor receptor (EGFR), ERBB2 (HER2/neu), MYC, CDKN2A (p16), SMAD4, MET, CCND1 (cyclin D1), CTNNB1 (β-catenin), and TP53 (p53), in histologic sections of endoscopic biopsies of 86 patients with BE in various stages of neoplastic progression. The markers, except SMAD4, were scored as 0 (50%). All markers, except EGFR, showed a significant trend for immunohistochemical protein overexpression during malignant progression in BE (P P <.001). β-Catenin can be helpful for a diagnosis of LGD in BE, although it stains positively in a subset only, whereas p53 remains an appropriate marker to define HGD. In case of doubt, cyclin D1 can be added to separate LGD from HGD in BE.
- Subjects
HISTOPATHOLOGY; DYSPLASIA; CANCER cells
- Publication
American Journal of Clinical Pathology, 2008, Vol 130, Issue 5, p745
- ISSN
0002-9173
- Publication type
Article
- DOI
10.1309/AJCPO31THGVEUIDH