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- Title
Frequent occurrence of cytogenetic abnormalities in sporadic nonmedullary thyroid carcinoma.
- Authors
Jenkins, Robert B.; Hay, Ian D.; Herath, John F.; Schultz, Cloann G.; Spurbeck, Jack L.; Grant, Clive S.; Goellner, John R.; Dewald, Gordon W.; Jenkins, R B; Hay, I D; Herath, J F; Schultz, C G; Spurbeck, J L; Grant, C S; Goellner, J R; Dewald, G W
- Abstract
Cytogenetic studies may provide important clues to the molecular pathogenesis of thyroid neoplasia. Thus, the authors attempted cytogenetic studies on 12 thyroid carcinomas: seven papillary, three follicular, and two anaplastic. Successful cytogenetic results were obtained on all 12 tumors; nine (75%) had one or more chromosomally abnormal clones. Four of the papillary carcinomas had a simple clonal karyotype, and three had no apparent chromosome abnormality. All four abnormal papillary tumors contained an anomaly of a chromosome 10q arm. In one instance, an inv(10)(q11.2q21.2) was observed in a Grade 2 papillary carcinoma as the sole acquired abnormality. In another case, an inversion or insertion involving 10q21.2 was found in a Grade 1 papillary tumor. The karyotype of a third tumor, a Grade 1 papillary carcinoma, was 46,XX,der(5)t(5;10)(p15.3;q11),der(9)t(9;?)(q11;?). A fourth abnormal papillary carcinoma, a Grade 1 tumor, had a t(6;10)(q21;q26.1) as the sole abnormality. Each of the five follicular or anaplastic carcinomas had a complex clonal karyotype. The three follicular carcinomas contained an abnormality of 3p25-p21, along with several other chromosome abnormalities.
- Subjects
ADENOCARCINOMA; CANCER; CELLS; CHROMOSOME abnormalities; CHROMOSOMES; KARYOTYPES; SEX chromosome abnormalities; THYROID gland tumors
- Publication
Cancer (0008543X), 1990, Vol 66, Issue 6, p1213
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19900915)66:6<1213::AID-CNCR2820660622>3.0.CO;2-9