We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area.
- Authors
Dorfman, Jeffrey R.; Bejon, Philip; Ndungu, Francis M.; Langhorne, Jean; Kortok, Moses Mosobo; Lowe, Brett S.; Mwangi, Tabitha W.; Williams, Thomas N.; Marsh, Kevin
- Abstract
To gain insight into why antibody responses to malarial antigens tend to be short lived, we studied antigen-specific memory B cells from donors in an area where malaria is endemic. We compared antibody and memory B cell responses to tetanus toxoid with those to 3 Plasmodium falciparum candidate vaccine antigens: the C-terminal portion of merozoite surface protein 1 (MSP1(19)), apical membrane antigen 1 (AMA1), and the cysteine-rich interdomain region 1 alpha (CIDR1 alpha ) of a protein from the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. These data are the first to be generated on memory B cells in children who are in the process of acquiring antimalarial immunity, and they reveal defects in B cell memory to P. falciparum antigens. Compared with the results for tetanus toxoid, more donors who were positive for antibody to AMA1 and CIDR1 alpha were negative for memory B cells. These data imply that some exposures to malaria do not result in the establishment of stable populations of circulating antigen-specific memory B cells, suggesting possible mechanisms for the short-lived nature of many anti-malarial antibody responses.
- Subjects
PLASMODIUM falciparum; ANTIGENS; MALARIA; B cells; IMMUNOLOGIC memory; IMMUNITY; MEMBRANE proteins; IMMUNOGLOBULINS
- Publication
Journal of Infectious Diseases, 2005, Vol 191, Issue 10, p1623
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/429671