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- Title
Na.
- Authors
Catterall, William A.
- Abstract
Voltage-gated Na channels are the molecular targets for mutations that cause several epilepsy syndromes. Mutations that impair the function of Na1.1 channels cause reduced Na currents and failure of electrical excitability in γ-aminobutyric acid (GABA)ergic interneurons, providing a potential mechanism for hyperexcitability in a spectrum of Na channel epilepsy syndromes. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at ).
- Subjects
EPILEPSY; GABA; AMINO acids; SEIZURES (Medicine); BRAIN diseases
- Publication
Epilepsia (Series 4), 2010, Vol 51, p59
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1111/j.1528-1167.2010.02845.x