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- Title
Evaluation of Sentinel Lymph Node Biopsy and Axillary Lymph Node Dissection for Breast Cancer Treatment Concepts - a Retrospective Study of 1,214 Breast Cancer Patients.
- Authors
Stein, Roland G.; Fricker, Roland; Rink, Thomas; Fitz, Hartmut; Blasius, Sebastian; Diessner, Joachim; Häusler, Sebastian F.M.; Stüber, Tanja N.; andreas, Victoria; Wöckel, achim; Müller, Thomas
- Abstract
Background: Most breast cancer patients require lumpectomy with axillary sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND). The ACOSOG Z0011-trial failed to detect significant effects of ALND on disease-free and overall survival among patients with limited sentinel lymph node (SLN) metastases. Intense dose-dense chemotherapy and supraclavicular fossa radiation (SFR) are indicated for patients with extensive axillary metastases. In this multicentered study, we investigated the relevance of ALND after positive SLNB to determine adequate adjuvant therapy. Methods: We retrospectively analyzed data from 1,214 patients with clinically nodal negative T1-T2 invasive breast cancer undergoing surgery at Hanau City Hospital Breast cancer center. Results: 681 patients underwent ALND after SLNB. 20 patients (8.5%) from the group with 1 or 2 SLN metastases (n = 236) showed more than 3 lymph node metastases after ALND. 13 patients (31.7%) from the group with more than 2 SLN metastases (n = 41) were diagnosed with a minimum of 4 axillary lymph node metastases after ALND. Conclusions: In 8.5% of the patients with 1 or 2 SLN metastases, ALND detected more than 3 macrometastases, setting the indication for intense dose-dense chemotherapy and SFR. More than 2 SLN metastases, T stage and grading predict lymph node metastases.
- Subjects
GERMANY; AXILLA; BREAST tumors; CANCER chemotherapy; SURGICAL excision; LYMPH node surgery; METASTASIS; SURVIVAL; RETROSPECTIVE studies; SENTINEL lymph node biopsy
- Publication
Breast Care, 2017, Vol 12, Issue 5, p324
- ISSN
1661-3791
- Publication type
Article
- DOI
10.1159/000477610