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- Title
Biomarkers in acute kidney injury.
- Authors
Ostermann, Marlies; Legrand, Matthieu; Meersch, Melanie; Srisawat, Nattachai; Zarbock, Alexander; Kellum, John A.
- Abstract
Acute kidney injury (AKI) is a multifactorial syndrome with a high risk of short- and long-term complications as well as increased health care costs. The traditional biomarkers of AKI, serum creatinine and urine output, have important limitations. The discovery of new functional and damage/stress biomarkers has enabled a more precise delineation of the aetiology, pathophysiology, site, mechanisms, and severity of injury. This has allowed earlier diagnosis, better prognostication, and the identification of AKI sub-phenotypes. In this review, we summarize the roles and challenges of these new biomarkers in clinical practice and research.
- Subjects
CREATININE; THERAPEUTICS; RENAL replacement therapy; CLINICAL medicine research; DIURESIS; ACUTE kidney failure; SEVERITY of illness index; BIOMARKERS; MEDICAL practice; PHENOTYPES
- Publication
Annals of Intensive Care, 2024, Vol 14, Issue 1, p1
- ISSN
2110-5820
- Publication type
Article
- DOI
10.1186/s13613-024-01360-9