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- Title
A Rapidly Developing Nodule in a Patient With Hairy Cell Leukemia in Remission: Merkel Cell Carcinoma: A Case Report.
- Authors
SACHANAS, SOTIRIOS; STEFANAKI, CHRISTINA; MARINOS, LEONIDAS; YIAKOUMIS, XANTHI; MOSCHOGIANNIS, MARIA; KOULIERIS, EFSTATHIOS; EFSTATHOPOULOU, MARIA; PANGALIS, GERASSIMOS A.
- Abstract
Background/Aim: Hairy cell leukemia (HCL) is a well-known lymphoproliferative disease with very effective treatment approaches primarily relying on purine analogues. However, these treatments are associated with profound and prolonged immunosuppression. Merkel cell carcinoma (MCC) is a rare and extremely aggressive skin tumor with an increased incidence in immunocompromised patients. Case Report: We report a case of a patient with HCL who was diagnosed with MCC, while in remission following retreatment with pentostatin, which induced a profound decrease in CD4 (+) T-cells. Conclusion: Our case provides further evidence supporting the hypothesis of a significant association between immunosuppression and MCC pathogenesis.
- Publication
In Vivo, 2024, Vol 38, Issue 5, p2540
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.13727