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- Title
Associations of sedentary behavior and screen time with biomarkers of inflammation and insulin resistance.
- Authors
Coughlin, Grace H.; Antush, Maximilian T.; Vella, Chantal A.
- Abstract
Sedentary behavior (SB) has been linked to risk factors of cardiometabolic disease, with inconsistent findings reported in the literature. We aimed to assess the associations of SB with multiple biomarkers of inflammation and insulin resistance in adults. Domain-specific SB, sitting time and moderate-to-vigorous physical activity (MVPA) were measured in 78 adults (mean ± SD 52.0 ± 10.8 y). Body fat percentage (BF%) was assessed using multi-frequency bioelectrical impedance. A blood draw assessed glucose, insulin, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin. Adiponectin-leptin ratio (ALR), homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β) were calculated. Multivariable linear regression analyses, controlling for age, sex, MVPA, and BF%, were used to assess associations. After adjustment for age, sex and MVPA, total SB (7.5 ± 2.5 h/day) was positively associated with leptin, insulin, HOMA-IR, HOMA-β (Standardized Beta (β) range 0.21–0.32) and negatively associated with ALR (β = -0.24, p < 0.05 for all). Similarly, total sitting time (7.2 ± 2.9 h/day) was associated with TNF-α (β = 0.22) and ALR (β = -0.26). These associations were attenuated to non-significance after adjustment for BF%. Leisure screen time was detrimentally associated with IL-6 (β = 0.24), leptin (β = 0.21), insulin (β = 0.37), HOMA-IR (β = 0.37), and HOMA-β (β = 0.34), independent of age, sex and MVPA (p < 0.05 for all). Only the associations with insulin (β = 0.26), HOMA-IR (β = 0.26), and HOMA-β (β = 0.23) remained significant after further controlling BF% (p < 0.05). Self-reported SB is associated with biomarkers of inflammation and insulin resistance, independent of MVPA, and in some cases BF%.
- Subjects
RISK assessment; SELF-evaluation; HEALTH status indicators; ADIPOSE tissues; LEPTIN; HOMEOSTASIS; RESEARCH funding; SEDENTARY lifestyles; PANCREATIC beta cells; MULTIPLE regression analysis; SEX distribution; SCREEN time; AGE distribution; BIOELECTRIC impedance; INSULIN; DESCRIPTIVE statistics; INSULIN resistance; LEISURE; BLOOD sugar; ADIPONECTIN; INFLAMMATION; BIOMARKERS; PHYSICAL activity; C-reactive protein; INTERLEUKINS; TUMOR necrosis factors; DISEASE risk factors
- Publication
Journal of Behavioral Medicine, 2024, Vol 47, Issue 5, p828
- ISSN
0160-7715
- Publication type
Article
- DOI
10.1007/s10865-024-00498-y