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- Title
Efficacy and Safety of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis: A Systematic Review and Meta-Analysis.
- Authors
Yang, Teng-Kai; Wang, Yu-Jen; Li, Hsing-Ju; Yu, Ya-Fang; Huang, Kai-Wen; Cheng, Jason Chia-Hsien
- Abstract
Background: Radiation-induced hemorrhagic cystitis (RHC) is a chronic inflammatory disease in patients undergoing radiation therapy that causes a cluster of symptoms which may have a latent period of months to years. The current non-invasive treatments include drug treatment and hyperbaric oxygen therapy (HBOT), which has been widely applied for RHC so far but with limited evidence. Thus, we conducted a systematic review and meta-analysis to clarify the effects and safety of HBOT for RHC. Methods: A systematic review and meta-analysis were utilized, searching in the databases of Embase, Pubmed, and Web of Science. The primary endpoint of the present study was complete remission of hematuria. The meta-analysis was conducted using a random effects model, and a pooled odds ratio with 95% CI was calculated. Results: A total of 317 studies were searched and fourteen articles with 556 patients were collected. The results showed that a total of 500 patients (89.9%) had symptom improvement, and the pooled results demonstrated that 55% of patients with HBOT had complete remission of hematuria (95% CI 51–59%). Conclusions: A significant improvement of symptoms when treated with HBOT was shown in this meta-analysis for patients with RHC.
- Subjects
HYPERBARIC oxygenation; RANDOM effects model; CHRONICALLY ill; RADIOTHERAPY; DATABASE searching
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 16, p4724
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13164724