We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Induction of Cyclooxygenase-2 in Ras-Transformed Human Mammary Epithelial Cells Undergoing Apoptosis.
- Authors
NA, HYE-KYUNG; SURH, YOUNG-JOON
- Abstract
A bstract: COX-2 expression has been reported to be elevated in several forms of human cancer. The presence of oncogenic ras has been associated with constitutive induction of COX-2, which confers resistance to apoptosis. Contrary to the above notion, we have found that H- ras-transformed human breast epithelial (MCF10A- ras) cells treated with the anticancer drug ET-18-O-CH3 exhibit an increased expression of COX-2, while they still undergo apoptosis. To determine whether the induction of COX-2 by ET-18-O-CH3 could contribute to apoptosis in MCF10A- ras cells, the selective COX-2 inhibitor celecoxib (SC-58635) was used. Celecoxib treatment attenuated ET-18-O-CH3-induced cell death. Taken together, the above findings suggest that COX-2 up-regulation does not necessarily confer the resistance to apoptosis in ras-transformed cells, but rather may sensitize these cells to apoptotic death.
- Publication
Annals of the New York Academy of Sciences, 2002, Vol 973, Issue 1, p153
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2002.tb04626.x