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- Title
Detection of biomolecules using optoelectronic biosensor based on localized surface plasmon resonance. Nanoimprint lithography approach.
- Authors
Chegel, V.; Lucas, B.; Guo, J.; Lopatynskyi, A.; Lopatynska, O.; Poperenko, L.
- Abstract
In this work, we use a nanoimprint lithography fabrication technology to create uniformly-oriented and homogenous noble metal nanoparticle arrays with well-controlled size, shape and spacing, which can be the basis platform for the development of Localized Surface Plasmon Resonance (LSPR) sensors for biomolecular detection. Using this approach, we demonstrate proof-of-principle of an optical biosensor to quantify biomolecular interactions in a real-time mode using a UV-visible spectrophotometer. The sensor shows concentration-dependent kinetics of surface adsorption or binding of biomolecules and a capability to monitor antigen-antibody specific reactions, which is demonstrated by the reaction between bovine serum albumin (BSA) and anti-BSA immunoglobulin.
- Subjects
BIOMOLECULES; OPTOELECTRONIC devices; BIOSENSORS; SURFACE plasmon resonance; LITHOGRAPHY; SURFACES (Physics); CHEMICAL reactions
- Publication
Semiconductor Physics, Quantum Electronics & Optoelectronics, 2009, Vol 12, Issue 1, p91
- ISSN
1560-8034
- Publication type
Article
- DOI
10.15407/spqeo12.01.091