We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Assessing severity of COVID-19 and the development of multi system inflammatory syndrome in children (MIS-C) in pediatric patients with atopic disease.
- Authors
Rudsenske, Natalie E.; Perkins, Jessica B.
- Abstract
Background: Research surrounding the coronavirus disease 2019 (COVID-19) pandemic and its impact on patients who are atopic has mainlyfocused on adults. A.fter the delta variant showed increased rates of COVID-19 in children. the pediatric population needs to be assessed as well. Objective: The objective was to assess and report outcomes in patients with COVID-19 and with and without certain atopic diseases in our patient collort at the University of Mississippi Medical Center. Methods: We conducted a retrospective review of patients by using a de-identified data base that allows querying via medical claims codes from the University of Mississippi Medical Center's Research Data Warehouse. We searched for patients who were COVID-19 positive and ages 0-21 years from January 1, 2020, to December 31, 2021. We then divided this population into two cohorts: an atopic population and a non-atopic population. The incidence Of hospitalizations, intensive care unit (ICU) admissions, death, length of stay, inhaled corticosteroid prescription history, and the incidence of multi-system inflammatory syndrome in children (MIS-0 outcomes in the two populations were collected. Results: There were 5261 patients ages 0-21 years and with conjirmed COVID-19. After exclusion criteria were applied, there were 1420 patients in the atopic cohort and 2525 patients in the non-atopic cohort. There were more hospitalizations and a longer length of stay in the atopic population. Mortality was equivalent in the atopic and non-atopic populations. There were more ICU admissions in the atopic population. There were 101 patients total with the diagnosis of MIS-C. and the incidence of MIS-C was similar in the atopic and non-atopic populations. There were more patients who were atopic on inhaled corticosteroid than were the patients who were non-atopic. Conclusion: This study sought to further elucidate whether asthma, atopic dermatitis, and allergic rhinitis in pediatric patients was associated with severe COVID-19. Our study showed increased hospitalizations, length of stay, and intensive care in the atopic population but similar outcomes in mortality and the development of MIS-C. Future longitudinal prospective studies are needed to assess the long-term effects on patient's atopic disease after COVID-19 infection.
- Subjects
UNIVERSITY of Mississippi; CHILD patients; MULTISYSTEM inflammatory syndrome in children; SYNDROMES in children; COVID-19; SARS-CoV-2 Delta variant; CORONAVIRUS diseases; ATOPY
- Publication
Allergy & Asthma Proceedings, 2024, Vol 45, Issue 2, p92
- ISSN
1088-5412
- Publication type
Article
- DOI
10.2500/aap.2024.45.230087