We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Segmental vitiligo: a randomized controlled trial to evaluate efficacy and safety of 0.1% tacrolimus ointment vs 0.05% fluticasone propionate cream.
- Authors
Kathuria, Sushruta; Khaitan, Binod K.; Ramam, M.; Sharma, Vinod K.
- Abstract
<bold>Background: </bold>Segmental vitiligo is a small subset of vitiligo which responds very well to surgical therapy, but the role of medical treatment is not very well defined.<bold>Aim: </bold>To compare the efficacy and safety of 0.1% tacrolimus ointment versus 0.05% fluticasone propionate cream in patients of segmental vitiligo.<bold>Methods: </bold>A randomized control trial was conducted in a tertiary care hospital on 60 consecutive patients with segmental vitiligo. Patients with segmental vitiligo exclusively or along with focal vitiligo, untreated or had not taken any topical treatment in previous 1 month or systemic treatment in previous 2 months, from May 2005 to January 2007, were block randomized into two groups. Children <5 years, pregnant and lactating women, and patients with known hypersensitivity to either drug and with associated multiple lesions of vitiligo were excluded. Group A (n = 29) patients were treated with tacrolimus 0.1% ointment twice daily and group B (n = 31) patients were treated with 0.05% of fluticasone cream once daily for 6 months. Response and side effects were recorded clinically and by photographic comparison.<bold>Results: </bold>Nineteen patients treated with tacrolimus and 21 patients treated with fluticasone completed the treatment with median repigmentation of 15% and 5%, respectively, at 6 months (P = 0.38). Transient side effects limited to the application site were observed.<bold>Conclusions: </bold>Both tacrolimus and fluticasone propionate produce variable but overall unsatisfactory repigmentation in segmental vitiligo.
- Subjects
INDIA; VITILIGO; RANDOMIZED controlled trials; TREATMENT effectiveness; TACROLIMUS; OINTMENTS; IMMUNOSUPPRESSIVE agents; LACTATION; LONGITUDINAL method; PROBABILITY theory; PROPIONATES; STATISTICAL sampling; MATHEMATICAL variables; SAMPLE size (Statistics); PILOT projects; DATA analysis software; MANN Whitney U Test
- Publication
Indian Journal of Dermatology, Venereology & Leprology, 2012, Vol 78, Issue 1, p68
- ISSN
0378-6323
- Publication type
journal article
- DOI
10.4103/0378-6323.90949