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- Title
CEA is an Independent Prognostic Indicator that is Associated with Reduced Survival and Liver Metastases in SCLC.
- Authors
Yang, Xueqin; Wang, Dong; Yang, Zhenzhou; Qing, Yi; Zhang, Zhimin; Wang, Ge; Yang, Zhixiang; Wang, Zhengbo
- Abstract
Small-cell lung cancer (SCLC) is classified into two stages, limited-stage small-cell lung cancer (LS-SCLC) and extensive-stage small-cell lung cancer (ES-SCLC), with ES-SCLC being associated with reduced survival. However, disease stage alone is not a very precise predictor of survival time. The aim of this study is to search for a prognostic indicator that can be used in conjunction with the staging system in SCLC. We performed a prospective analysis of 116 patients with SCLC undergoing standard chemotherapy with or without radiotherapy. Expression levels of 12 tumor markers were measured at the time of diagnosis by a commercial protein chip system, and patients were followed up for a maximum of 54 weeks. CEA was the most frequently detected tumor marker in SCLC, with 32.8% of samples scoring positive, and was also the only marker that correlated with overall survival. The average survival time was 16.78 months for patients with CEA below 5 ng/ml and 11.4 months for patients with CEA above 5 ng/ml ( P < 0.001). In contrast, no association was found between tumor stage and overall survival. CEA expression was independent of tumor stage ( P = 0.930). CEA is an independent prognostic factor that can be used in conjunction with disease stage in SCLC.
- Subjects
LIVER metastasis; SMALL cell lung cancer; TUMOR markers; RADIOTHERAPY; MEDICAL radiology
- Publication
Cell Biochemistry & Biophysics, 2011, Vol 59, Issue 2, p113
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-010-9121-0