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- Title
Membrane traffic related to endosome dynamics and protein secretion in filamentous fungi.
- Authors
Higuchi, Yujiro
- Abstract
In eukaryotic cells, membrane-surrounded organelles are orchestrally organized spatiotemporally under environmental situations. Among such organelles, vesicular transports and membrane contacts occur to communicate each other, so-called membrane traffic. Filamentous fungal cells are highly polarized and thus membrane traffic is developed to have versatile functions. Early endosome (EE) is an endocytic organelle that dynamically exhibits constant long-range motility through the hyphal cell, which is proven to have physiological roles, such as other organelle distribution and signal transduction. Since filamentous fungal cells are also considered as cell factories, to produce valuable proteins extracellularly, molecular mechanisms of secretory pathway including protein glycosylation have been well investigated. In this review, molecular and physiological aspects of membrane traffic especially related to EE dynamics and protein secretion in filamentous fungi are summarized, and perspectives for application are also described.
- Subjects
FILAMENTOUS fungi; SECRETION; EUKARYOTIC cells; BIOLOGICAL transport; ENDOCYTOSIS; CELLULAR signal transduction
- Publication
Bioscience, Biotechnology & Biochemistry, 2021, Vol 85, Issue 5, p1038
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1093/bbb/zbab004