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- Title
Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin.
- Authors
Ishibashi, Fumito; Fukuda, Tsutomu; Zha, Shijiao; Hashirano, Aya; Hirao, Shotaro; Iwao, Masatomo
- Abstract
Benzo[ g ][1]benzopyrano[4,3- b ]indol-6(13 H)-ones (BBPIs) are potent anticancer compounds having unique BBPIs ring system designed on the basis of the marine natural product lamellarin D. In this study, we describe an alternative synthesis of a 2-demethoxy series of BBPIs, employing van Leusen pyrrole synthesis and an intramolecular Heck reaction as the key reactions. Cytotoxicity of the derivatives against several cancer and normal cell lines is reported.
- Subjects
DNA topoisomerase I; MARINE natural products; ANTINEOPLASTIC agents; HECK reaction; PYRROLE derivatives; CYTOTOXINS; ALKALOIDS; MARINE toxins
- Publication
Bioscience, Biotechnology & Biochemistry, 2021, Vol 85, Issue 1, p181
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1093/bbb/zbaa028