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- Title
Construction of Various Bridged Polycyclic Skeletons by Palladium‐Catalyzed Dearomatization.
- Authors
Mu, Xingye; Yu, Hanxiao; Peng, Henian; Xiong, Wenrui; Wu, Ting; Tang, Wenjun
- Abstract
A powerful palladium‐catalyzed dearomative cyclization was developed that provides facile access to eight types of bridged tetracyclic skeletons bearing various ring sizes and heterocycles. With this method, several skeletons or analogues of natural products, including tubingensin B and dracaenones, were synthesized. Asymmetric dearomative cyclization enables the construction of various enantiomerically enriched bridged polycyclic systems with up to 99 % ee by employing a chiral palladium catalyst.
- Subjects
PALLADIUM; PALLADIUM catalysts; NATURAL products; CONSTRUCTION
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 21, p8220
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202000953