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- Title
Ligand-Enabled Auxiliary-Free meta-C−H Arylation of Phenylacetic Acids.
- Authors
Li, Gen ‐ Cheng; Wang, Peng; Farmer, Marcus E.; Yu, Jin ‐ Quan
- Abstract
The meta-C−H arylation of free phenylacetic acid was realized using 2-carbomethoxynorbornene (NBE-CO2Me) as a transient mediator. Both the modified norbornene and the mono-protected 3-amino-2-hydroxypyridine type ligand are crucial for this auxiliary-free meta-C−H arylation reaction. A series of phenylacetic acids, including mandelic acid and phenylglycine, react smoothly with various aryl iodides to provide the meta-arylated products in high yields.
- Subjects
PHENYLACETIC acid; ARYL iodides; CARBON dioxide; ARYLATION; LIGANDS (Chemistry)
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 24, p6978
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201702686