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- Title
Design and Enantioselective Construction of Axially Chiral Naphthyl-Indole Skeletons.
- Authors
Zhang, Hong-Hao; Wang, Cong-Shuai; Li, Can; Mei, Guang-Jian; Li, Yuxue; Shi, Feng
- Abstract
The first enantioselective construction of a new class of axially chiral naphthyl-indole skeletons has been established by organocatalytic asymmetric coupling reactions of 2-naphthols with 2-indolylmethanols (up to 99 % yield, 97:3 e.r.). This approach not only affords a new type of axially chiral heterobiaryl backbone, but also provides a new catalytic enantioselective strategy for constructing axially chiral biaryl scaffolds by making use of the C3-electrophilicity of 2-indolylmethanols.
- Subjects
INDOLE; METHANOL; ENANTIOSELECTIVE catalysis; ORGANOCATALYSIS; TISSUE scaffolds
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 1, p122
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201608150