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- Title
Biomimetic Nanofluidic Diode Composed of Dual Amphoteric Channels Maintains Rectification Direction over a Wide pH Range.
- Authors
Sui, Xin; Zhang, Zhen; Zhang, Zhenyu; Wang, Zhiwei; Li, Chao; Yuan, Hao; Gao, Longcheng; Wen, Liping; Fan, Xia; Yang, Lijun; Zhang, Xinru; Jiang, Lei
- Abstract
pH-gated ion channels in cell membranes play important roles in the cell's physiological activities. Many artificial nanochannels have been fabricated to mimic the natural phenomenon of pH-gated ion transport. However, these nanochannels show pH sensitivity only within certain pH ranges. Wide-range pH sensitivity has not yet been achieved. Herein, for the first time, we provide a versatile strategy to increase the pH-sensitive range by using dual amphoteric nanochannels. In particular, amphoteric polymeric nanochannels with carboxyl groups derived from a block copolymer (BCP) precursor and nanochannels with hydroxyl groups made from anodic alumina oxide (AAO) were used. Due to a synergistic effect, the hybrid nanochannels exhibit nanofluidic diode properties with single rectification direction over a wide pH range. The novel strategy presented here is a scalable, low-cost, and robust alternative for the construction of large-area membranes for nanofluidic applications, such as the separation of biomolecules.
- Subjects
NANOFLUIDIC devices; DIODES; BIOMIMETIC chemicals; PH effect; BLOCK copolymers; ALUMINUM oxide; AMPHOTERIC substances; ION mobility
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 42, p13250
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201606469