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- Title
Silver-Mediated Intermolecular 1,2-Alkylarylation of Styrenes with α-Carbonyl Alkyl Bromides and Indoles.
- Authors
Ouyang, Xuan ‐ Hui; Song, Ren ‐ Jie; Hu, Ming; Yang, Yuan; Li, Jin ‐ Heng
- Abstract
A new iron-facilitated silver-mediated radical 1,2-alkylarylation of styrenes with α-carbonyl alkyl bromides and indoles is described, and two new C−C bonds were generated in a single step through a sequence of intermolecular C(sp3)−Br functionalization and C(sp2)−H functionalization across the alkenes. This method provides an efficient access to alkylated indoles with broad substrate scope and excellent selectivity.
- Subjects
ALKYL bromides; INDOLE compounds; CARBON-Carbon Advanced Technologies Inc.; INTERMOLECULAR interactions; ALKENES
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 9, p3239
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201511624