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- Title
Two-Component Supramolecular Gels Derived from Amphiphilic Shape-Persistent Cyclo[6]aramides for Specific Recognition of Native Arginine.
- Authors
He, Youzhou; Xu, Min; Gao, Rongzhao; Li, Xiaowei; Li, Fengxue; Wu, Xuedan; Xu, Dingguo; Zeng, Huaqiang; Yuan, Lihua
- Abstract
A unique supramolecular two-component gelation system was constructed from amphiphilic shape-persistent cyclo[6]aramides and diethylammonium chloride (or triethylammonium chloride). This system has the ability to discriminate native arginine from 19 other amino acids in a specific fashion. Cyclo[6]aramides show preferential binding for the guanidinium residue over ammonium groups. This specificity was confirmed by both experimental results and theoretical simulations. These results demonstrated a new modular displacement strategy, exploring the use of species-binding hydrogen-bonded macrocyclic foldamers for the construction of two-component gelation systems for selective recognition of native amino acids by competitive host-guest interactions. This strategy may be amenable to developing a variety of functional two-component gelators for specific recognition of various targeted organic molecular species.
- Subjects
SUPRAMOLECULES; SUPRAMOLECULAR chemistry; GELATION; ARGININE; AMINO acids
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 44, p12028
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201407092