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- Title
Preparation and antibacterial activity of injectable methylcellulose/chitosan double network hydrogel.
- Authors
Jiang, Bo-Nan; Li, Dan; Zou, Xue-Na; Wei, Hui-Ge; Zhong, Cheng; Chu, Li-Qiang
- Abstract
Biopolymer-based injectable hydrogels with antibacterial activity have attracted considerable attention for biomedical applications. Herein, we report on an effective preparation of injectable double network hydrogel by adding zinc acetate (ZnOAc2) into an aqueous mixture of methylcellulose (MC) and chitosan (CS) at room temperature and then heating to T = 37 °C, in which the complexation of the CS with Zn2+ ion took place immediately and the MC underwent thermogelation at elevated temperature. The influence of both the CS and different salts (i.e., Zn(NO3)2, ZnCl2 and ZnOAc2) on the thermogelation of MC solution was investigated via inverted vial test and UV–Vis measurement. The results indicated that the thermogelation temperature of 1.0% w/v MC was about 60.8 °C, which decreased to 35.7 °C when mixed with 1.0% w/v CS and 0.3 mol/L sodium acetate. The mechanical properties of various hydrogels were evaluated via rheological analysis at different temperatures. A detailed study about the antibacterial activities of the resulting MC/CS hydrogels was carried out against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, confirming that the MC/CS double network hydrogel indeed exhibited excellent antibacterial activity when compared with pristine thermo-responsive MC hydrogel. At last, the injectability of the MC/CS hydrogel was also evaluated on a home-built double-syringe injection device.
- Subjects
METHYLCELLULOSE; ANTIBACTERIAL agents; CHITOSAN; SODIUM acetate; ZINC acetate; HIGH temperatures; HYDROGELS; CHONDROITIN sulfates
- Publication
Cellulose, 2023, Vol 30, Issue 16, p10357
- ISSN
0969-0239
- Publication type
Article
- DOI
10.1007/s10570-023-05516-x