We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Navigation using indocyanine green fluorescence imaging for hepatoblastoma pulmonary metastases surgery.
- Authors
Kitagawa, Norihiko; Shinkai, Masato; Mochizuki, Kyoko; Usui, Hidehito; Miyagi, Hisayuki; Nakamura, Kaori; Tanaka, Mio; Tanaka, Yukichi; Kusano, Mitsuo; Ohtsubo, Seiji
- Abstract
To achieve precise and sensitive detection of chemotherapy-resistant hepatoblastoma pulmonary metastases, we performed surgery using indocyanine green (ICG) fluorescence imaging navigation. Lung metastasectomies were performed in 10 patients aged from 1 to 11 years. ICG (0.5 mg/kg) was injected intravenously 24 h before the operation. After a thoracotomy had been performed, a 760-nm infrared ray was applied to the lung using a generator and the 830-nm evoked fluorescence was collected and visualized on a real-time display. In total, 250 fluorescence-positive lesions were extirpated in 37 operations. All of the pathologically positive lesions were clearly fluorescence positive. The diameter of the smallest detectable lesion was 0.062 mm. In two patients, there were 29 extirpated lesions that were pathologically proven not to be hepatoblastoma metastases. Although a problem of false positive remains, this method is very useful for the detection of small pulmonary metastases.
- Subjects
INDOCYANINE green; LUNG cancer treatment; LUNG surgery; METASTASIS; INFRARED radiation in medicine; TISSUE wounds
- Publication
Pediatric Surgery International, 2015, Vol 31, Issue 4, p407
- ISSN
0179-0358
- Publication type
Article
- DOI
10.1007/s00383-015-3679-y