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- Title
Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience.
- Authors
Chang, Suyon; Hur, Jin; Im, Dong; Suh, Young; Hong, Yoo; Lee, Hye-Jeong; Kim, Young; Han, Kyunghwa; Kim, Dae; Lee, Chang; Shin, Ha; Choi, Byoung; Im, Dong Jin; Suh, Young Joo; Hong, Yoo Jin; Kim, Young Jin; Kim, Dae Joon; Lee, Chang Young; Shin, Ha Young; Choi, Byoung Wook
- Abstract
<bold>Objectives: </bold>To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas.<bold>Materials: </bold>Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis.<bold>Results: </bold>Of the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively).<bold>Conclusion: </bold>DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning.<bold>Key Points: </bold>• IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.
- Subjects
COMPUTED tomography; THYMOMA; TUMOR diagnosis; TUMOR treatment; CARCINOMA; DIAGNOSIS; THERAPEUTICS
- Publication
European Radiology, 2017, Vol 27, Issue 5, p1992
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4542-9