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- Title
CT measurement of breast glandular tissue and its association with testicular cancer.
- Authors
Klang, Eyal; Rozendorn, Noa; Raskin, Steve; Portnoy, Orith; Sklair, Miri; Marom, Edith; Konen, Eli; Amitai, Michal; Marom, Edith M; Amitai, Michal M
- Abstract
<bold>Objectives: </bold>To evaluate the associations between breast glandular tissues diameters as determined by CT and b-hCG levels, histological types, tumour spread and prognosis in patients with testicular germ cell tumour.<bold>Methods: </bold>Ninety-four patients with pre-treatment CT scan and markers (b-hCG, AFP, LDH) were retrospectively collected. A radiologist measured diameters in all CT examinations and correlation between diameters and log (b-hCG) was assessed (Pearson's coefficient). The ability of measured diameters to predict lymphatic and distant haematogenous metastatic spread was evaluated (ROC curves). The associations between measured diameter cut-off values of 20 and 25 mm and International Germ Cell Cancer Collaborative Group (IGCCCG) classification, lymphatic and distant haematogenous metastatic spread and histological subtypes were evaluated (chi squared test).<bold>Results: </bold>Breast glandular diameters correlated to log(b-hCG) (r = 0.579) and predicted distant haematogenous metastatic spread (AUC = 0.78). Worse prognosis (intermediate or poor IGCCCG) was shown for 20 mm (27.3 vs. 4.2 %, p = 0.005) and 25 mm (33.3 vs. 6.1 %, p = 0.014). A diameter of 25 mm was associated with non-seminoma (91.7 vs. 48.8 %, p = 0.005).<bold>Conclusion: </bold>Breast glandular tissue diameters correlated with log(b-hCG) and predicted distant haematogenous metastases. Twenty and 25 mm were associated with worse prognosis and 25 mm was able to distinguish between seminoma and non-seminoma.<bold>Key Points: </bold>• CT breast glandular tissue diameter correlates with log(b-HCG) • Gynaecomastia in CT is associated with worse prognosis • Gynaecomastia in CT is associated with non-seminoma histological subtype.
- Subjects
BREAST tumors; METASTASIS; LYMPHATICS; TESTICULAR cancer; SEMINOMA
- Publication
European Radiology, 2017, Vol 27, Issue 2, p536
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4414-3