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- Title
MR imaging of the brain in large cohort studies: feasibility report of the population- and patient-based BiDirect study.
- Authors
Teuber, Anja; Sundermann, Benedikt; Kugel, Harald; Schwindt, Wolfram; Heindel, Walter; Minnerup, Jens; Dannlowski, Udo; Berger, Klaus; Wersching, Heike
- Abstract
<bold>Objectives: </bold>To describe the implementation and protocol of cerebral magnetic resonance imaging (MRI) in the longitudinal BiDirect study and to report rates of study participation as well as management of incidental findings.<bold>Methods: </bold>Data came from the BiDirect study that investigates the relationship between depression and arteriosclerosis and comprises 2258 participants in three cohorts: 999 patients with depression, 347 patients with manifest cardiovascular disease (CVD) and 912 population-based controls. The study program includes MRI of the brain. Reasons for non-participation were systematically collected. Incidental findings were categorized and disclosed according to clinical relevance.<bold>Results: </bold>At baseline 2176 participants were offered MRI, of whom 1453 (67 %) completed it. Reasons for non-participation differed according to cohort, age and gender with controls showing the highest participation rate of 79 %. Patient cohorts had higher refusal rates and CVD patients a high prevalence of contraindications. In the first follow-up examination 69 % of participating subjects completed MRI. Incidental findings were disclosed to 246 participants (17 %). The majority of incidental findings were extensive white matter hyperintensities requiring further diagnostic work-up.<bold>Conclusions: </bold>Knowledge about subjects and sensible definition of incidental findings are crucial for large-scale imaging projects. Our data offer practical and concrete information for the design of future studies.<bold>Key Points: </bold>• Willingness to participate in MRI is generally high, also in follow-up examinations. • Rates of refusal and prevalence of contraindications differ according to subject characteristics. • Extensive white matter hyperintensities considerably increase the disclosure rates of incidental findings. • MRI workflow requires continuous case-by-case handling by an interdisciplinary team.
- Subjects
GERMANY; MAGNETIC resonance imaging of the brain; MENTAL depression; ARTERIOSCLEROSIS diagnosis; PATIENTS; CARDIOVASCULAR diseases; MAGNETIC resonance imaging; BRAIN; CEREBRAL arteriosclerosis; COMPARATIVE studies; DIAGNOSIS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PARTICIPATION; RESEARCH; SEX distribution; DISCLOSURE; PILOT projects; EVALUATION research; DISEASE prevalence; CASE-control method
- Publication
European Radiology, 2017, Vol 27, Issue 1, p231
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4303-9