We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The predictive value of preoperative F-fluorodeoxyglucose PET for postoperative recurrence in patients with localized primary gastrointestinal stromal tumour.
- Authors
Mikami, Yoshiki; Miyake, Kanae; Nakamoto, Yuji; Togashi, Kaori; Tanaka, Shiro; Higashi, Tatsuya; Tadamura, Eiji; Saga, Tsuneo; Minami, Shunsuke
- Abstract
Objectives: To assess the potential value of preoperative F-FDG PET to predict postoperative recurrence of solitary localized primary gastrointestinal stromal tumour (GIST) after radical resection. Methods: A total of 46 patients with primary GIST who received preoperative F-FDG PET and underwent complete resection without neoadjuvant therapy were retrospectively studied. PET findings, including ring-shaped uptake and intense uptake, were compared with Joensuu risk grades using Fisher's exact test. The prognostic value of the preoperative clinico-imaging variables-age ≥60 years, male, ring-shaped uptake, intense uptake, tumour size >5 cm, heterogeneous CT attenuation and lower gastrointestinal origin-and Joensuu high risk for recurrence-free survival was evaluated using log-rank test and multivariate Cox regression analysis. Results: Ring-shaped uptake and intense uptake were significantly associated with Joensuu high risk. Univariate analysis showed that ring-shaped uptake, intense uptake, size >5 cm and Joensuu high risk were significantly associated with inferior recurrence-free survival. Multivariate analysis showed that ring-shaped uptake ( P = 0.004) and Joensuu high risk ( P = 0.021) were independent adverse prognostic factors of postoperative recurrence. Conclusions: Ring-shaped uptake on preoperative F-FDG PET may be a potential predictor of postoperative tumour recurrence of localized primary GISTs. Key points : • Clinical course of resectable solitary localized primary GISTs varies widely. • Ring-shaped uptake is an independent adverse prognostic factor of postoperative recurrence. • Preoperative F- FDG PET may help predict postoperative recurrence of GISTs.
- Subjects
FLUORODEOXYGLUCOSE F18; GASTROINTESTINAL stromal tumors; PREOPERATIVE care; SURGICAL complications; UNIVARIATE analysis
- Publication
European Radiology, 2016, Vol 26, Issue 12, p4664
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-016-4242-5