We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer-a per lesion validation study.
- Authors
Lambregts DM; Maas M; Riedl RG; Bakers FC; Verwoerd JL; Kessels AG; Lammering G; Boetes C; Beets GL; Beets-Tan RG; Lambregts, Doenja M J; Maas, Monique; Riedl, Robert G; Bakers, Frans C H; Verwoerd, Jan L; Kessels, Alfons G H; Lammering, Guido; Boetes, Carla; Beets, Geerard L; Beets-Tan, Regina G H
- Abstract
<bold>Objectives: </bold>To evaluate the performance of diffusion-weighted MRI (DWI) in addition to T2-weighted (T2W) MRI for nodal restaging after chemoradiation in rectal cancer.<bold>Methods: </bold>Thirty patients underwent chemoradiation followed by MRI (1.5 T) and surgery. Imaging consisted of T2W-MRI and DWI (b0, 500, 1000). On T2W-MRI, nodes were scored as benign/malignant by two independent readers (R1, R2). Mean apparent diffusion coefficient (ADC) was measured for each node. Diagnostic performance was compared for T2W-MRI, ADC and T2W+ADC, using a per lesion histological validation.<bold>Results: </bold>ADC was higher for the malignant nodes (1.43 ± 0.38 vs 1.19 ± 0.27 *10⁻³ mm²/s, p < 0.001). Area under the ROC curve/sensitivity/specificity were 0.88/65%/93% (R1) and 0.95/71%/91% (R2) using T2W-MRI; 0.66/53%/82% using ADC (mean of two readers); and 0.91/56%/98% (R1) and 0.96/56%/99% (R2) using T2W+ADC. There was no significant difference between T2W-MRI and T2W+ADC. Interobserver reproducibility was good for T2W-MRI (κ0.73) and ADC (intraclass correlation coefficient 0.77).<bold>Conclusions: </bold>After chemoradiation, ADC measurements may have potential for nodal characterisation, but DWI on its own is not reliable. Addition of DWI to T2W-MRI does not improve accuracy and T2W-MRI is already sufficiently accurate.
- Publication
European Radiology, 2011, Vol 21, Issue 2, p265
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-010-1937-x