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- Title
Severity of hyperemesis gravidarum correlates with serum levels of reverse T3.
- Authors
Asakura, Hirobumi; Watanabe, Syouiti; Sekiguchi, Atsuko; Power, Gordon G.; Araki, Tsutomu; Asakura, H; Watanabe, S; Sekiguchi, A; Power, G G; Araki, T
- Abstract
To investigate the possible physiological relevance of extra-thyroidal production of reverse T3 (rT3) in hyperemesis gravidarum, measurements of serum rT3, free T3 (FT3), free T4, (FT4), and nonesterified fatty acids (NEFA) were correlated with weight loss of hyperemetic women. All the thyroid hormones, NEFAs and weight loss were significantly higher in hyperemesis gravidarum than in control subjects, and also higher than in those with milder symptoms of morning sickness (p < 0.05). Elevations of FT3, FT4 and NEFAs correlated with the extent of weight loss, the latter taken as the index of the severity of hyperemesis gravidarum (p < 0.05). Only rT3 correlated with both weight loss and the rate of lipolysis, as reflected by elevations of NEFAs (p < 0.05). The data are consistent with a shift from T3 to rT3 as products of 5'-monodeiodination of thyroxine in hyperemesis gravidarum. Because reverse T3 is physiologically inactive a control mechanism may be postulated wherein T3 production is minimized, thereby reducing weight loss and lipolysis in patients with hyperemesis gravidarum.
- Subjects
MORNING sickness; PREGNANCY complications; THYROID hormones; FATTY acid synthesis; LIPOLYSIS; WEIGHT loss; CATECHOLAMINES; COMPARATIVE studies; FATTY acids; GENETIC disorders; GESTATIONAL age; LIPID metabolism disorders; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SICKNESS Impact Profile; THYROXINE; EVALUATION research
- Publication
Archives of Gynecology & Obstetrics, 2000, Vol 264, Issue 2, p57
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s004049900052