We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Analysis of anti‐neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1‐antitrypsin‐deficient subjects.
- Authors
Audrain, Marie A. P.; Sesboüé, Richard; Baranger, Thierry A. R.; Elliott, Jane; Testa, Angelo; Martin, Jean‐Pierre; Lockwood, C. Martin; Esnault, Vincent L. M.
- Abstract
Background. ANCA are autoantibodies directed against polymorphonuclear cell antigens, mainly proteinase 3 (PR3) and myeloperoxidase (MPO), which are implicated in the pathogenesis of small‐vessel necrotizing vasculitis. Alpha1‐antitrypsin is the main inhibitor of neutral serine proteinase [i.e. human leukocyte elastase (HLE) and PR3] present in PMN alpha‐granules (αGr). An association first reported by us between PR3 ANCA and the deficient PiZZ phenotype in ANCA‐positive systemic vasculitis, now widely confirmed by others, led us to study the incidence and specificity of ANCA among PiZZ subjects.
- Publication
Nephrology Dialysis Transplantation, 2001, Vol 16, Issue 1, p39
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/16.1.39